Performing sample size calculation by hand in the era of new technologies would seem crazy. Nowadays, there are many statistical programs for estimation of sample size such as R, nMaster, SAS and other online sites. Most of them (such nMaster and SAS) are commercial distributions (quite expensive). The updated version of software named “My sample Size" (formerly IBI Sample Size), which is developed using visual Basic 2017 for sample size estimation. We are sure that this is going to be a big help to everyone, not only to the students but also to the researchers/faculty in their research for sample size estimation.